Inside each human cell, two meters of DNA is compacted by up to 20,000 fold in order to fit inside the nucleus. This incredible degree of compaction is achieved through hierarchically folding DNA around packaging proteins to form chromatin fibres, which further loop and coil to form condensed chromosomes. All fundamental processes such as DNA replication, repair, and gene transcription occur in the context of this chromatin complex; making the study of its structural features an essential step for understanding gene regulation and how it contributes to disease.
As a PhD researcher in the Gilbert Lab at the University of Edinburgh, my focus is on understanding the mechanisms behind higher-order chromatin folding. I utilize a combination of biochemical, biophysical and molecular methods to investigate the role of DNA sequence and nucleosome positioning in this process. My research has the potential to provide insights into the role of chromatin structure in regulating various biological processes and diseases.